Immunoglobulin g4 related mastitis: A case report

Abstract

Immunoglobulin (Ig)G4-related sclerosing disease is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. IgG4-related mastitis (IgG4-RM) is exceedingly rare with only thirteen cases reported in the literature to date. Immunoglobulin G4-RM is diagnosed exclusively on histological analysis. It is a benign chronic inflammatory process that can be treated sufficiently with excision or steroid. However, conservative treatment should be preferred and unnecessary surgery should be avoided as IgG4-RM respond to simple and effective steroid treatment. Herein, we presented a 28-year-old patient with IgG4-RM. She was the youngest patient in the literature at the time of her diagnosis.