A case report of malignant pleural mesothelioma with long‐term disease control after chemotherapy

Abstract

Long duration of responses to chemotherapy in patients with malignant pleural mesothelioma (MPM) is rare. The authoers report a patients with inoperable MPM who achieved complete remission with combination chemotherapy of cyclophosphamide, doxorubicin, and cisplatin. 5‐Fluorouracil and mitomycin C (FM) induced another remission after recurrence of the tumor. Retreatment with FM after chemotherapy had been stopped for 20 months yielded another continuing response. The overall tumor‐control time is more than 4 years. Literature reviews and the authors' results suggest that MPM may be a chemosensitive tumor in some patients. Additional evaluations of CAP, FM, and methotrexate combination regimens in this disease should be considered. Copyright © 1991 American Cancer Society