An amphiphilic, catalytically active, vitamin B12 derivative

Abstract

We performed the reaction of vitamin B12 with N, N-dimethylformamide dimethyl acetal for primary amide activation, and added MeOH as a nucleophile, to afford cobalester, the first amphiphilic cobalamin derivative. The unique combination of redox properties and solubility represents an asset for its use as a catalyst in C-C bond forming reactions. © 2014 The Partner Organisations.