Activity of Prefrontal Neurons Predict Future Choices during Gambling

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Abstract

Passecker et al. show that specialized neurons in the prelimbic cortex of rats predict the next choice during the outcome evaluation in a gambling task, even for unlikely or uncertain decisions. Disrupting the prelimbic cortex led to excessive risk taking.

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Passecker, J., Mikus, N., Malagon-Vina, H., Anner, P., Dimidschstein, J., Fishell, G., … Klausberger, T. (2019). Activity of Prefrontal Neurons Predict Future Choices during Gambling. Neuron, 101(1), 152-164.e7. https://doi.org/10.1016/j.neuron.2018.10.050

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