CoMMD3:Bmi1 fusion and COMMD3 protein regulate c-Myc transcription: Novel therapeutic target for metastatic prostate cancer

Abstract

Gene rearrangement is reported to be associated to the aggressive phenotype and poor prognosis in prostate cancer. We identified a gene fusion between a transcription repressor (BMI1) and transcriptional factor (COMMD3) in human prostate cancer. We show that COMMD3:BMI1 fusion expression is significantly increased in prostate cancer disease in an order: normal tissue < primary