Reproducibility of linear array for human papillomavirus genotyping

Abstract

We conducted a Linear Array test/retest analysis using cytologic specimens from 198 women. A total of 67.2% of samples had the same human papillomavirus (HPV) types detected in both tests (type-specific positive agreement was 83.3% overall [Kappa= 0.9] and 86.8% for carcinogenic types [Kappa=0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible. Copyright © 2013, American Society for Microbiology.