Toxic dermatitis induced by 10‐ethyl‐10‐deazaaminopterin (10‐EdAM), a novel antifolate

Abstract

A new methotrexate analog, 10‐ethyl‐10‐deaza‐aminopterin (10‐EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10‐EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing. Copyright © 1990 American Cancer Society