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Bioavailable vitamin D in chronic kidney disease

Kidney International
DOI: 10.1038/ki.2012.135
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Abstract

Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism. © 2012 International Society of Nephrology.

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Brown, A. J., & Coyne, D. W. (2012, July 1). Bioavailable vitamin D in chronic kidney disease. Kidney International. Nature Publishing Group. https://doi.org/10.1038/ki.2012.135

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