Vaccine Adverse Events and Adverse Reactions

Abstract

Vaccine adverse events are reported following immunization as vaccine adverse reactions in Japan. Vaccine adverse events are inevitable because vaccines induce protective immunity to reduce the severity of infection through the stimulation of innate immunity. Vaccine adverse events are registered by the Ministry of Health, Labour and Welfare (Committee of evaluation of vaccine adverse events). We analyzed the data reported as severe adverse events and death in the meeting from (Apr. 2013 to Feb. 2018). Some data reported form licensure to 2018. The incidence of serious adverse events following immunization with measles and rubella combined (MR), measles, rubella, mumps, and zoster monovalent vaccines was 0.51-1.91/100,000 doses and five cases of death after MR, one after mumps, and three after zoster vaccination, were reported during five years. That following, DTaP-IPV, IPV, Hib, PCV, Japanese Encephalitis vaccines was