GB virus C viremia is associated with higher levels of double-negative T cells and lower T-cell activation in HIV-infected individuals receiving antiretroviral therapy

Abstract

Double-negative T cells (DNTCs; ie, CD3+CD4-CD8 - T cells) play a role in limiting chronic immune activation. GB virus C (GBV-C) infection is associated with reduced T-cell activation in human immunodeficiency virus (HIV)-infected individuals. T-cell activation and DNTCs were measured in HIV-infected subjects with a nondetectable HIV load. GBV-C-viremic subjects had significantly reduced CD4+ and CD8 + T-cell activation (P =. 003 and. 034, respectively) and significantly increased DNTCs (P =. 038), compared with nonviremic subjects. GBV-C load correlated with DNTC percentage (P =. 004). Thus, GBV-C infection is associated with an increase in DNTCs, which may contribute to reduced immune activation during HIV infection. © 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.