Abstract
The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC50 2.3 × 10-4M) with 1.3 × 10-5M and 1.2 × 10-5M IC50 values, respectively, by interaction of the stable DPPH free radical. © 2005 Taylor & Francis.
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Ayhan-Kilcigil, G., Kuş, C., Çoban, T., Can-Eke, B., Özbey, S., & Iscan, M. (2005). Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles. Journal of Enzyme Inhibition and Medicinal Chemistry, 20(5), 503–514. https://doi.org/10.1080/14756360500287086
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