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Development of a human-murine chimeric immunoglobulin M for use in the serological detection of human alphavirus antibodies

Clinical and Vaccine Immunology (2011) 18(12) 2181-2182
DOI: 10.1128/CVI.05269-11
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Abstract

Diagnosis of human alphaviral infections relies on serological techniques, such as the immunoglobulin M antibody capture-enzyme-linked immunosorbent assay (MAC-ELISA). We have humanized the alphavirus broadly cross-reactive murine monoclonal antibody 1A4B-6 to create a reagent capable of replacing human positive sera in the MAC-ELISA for diagnosis of human alphaviral infections. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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Thibodeaux, B. A., Liss, N. M., Panella, A. N., & Roehrig, J. T. (2011). Development of a human-murine chimeric immunoglobulin M for use in the serological detection of human alphavirus antibodies. Clinical and Vaccine Immunology, 18(12), 2181–2182. https://doi.org/10.1128/CVI.05269-11

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