Biological Activity of Silver Nanoparticles and Their Applications in Anticancer Therapy

Abstract

Nanotechnology delivers materials and nanoparticles (NPs) with high biological poten- tial, useful in bioengineering, nanomedicine, and human health protection. Silver nanoparticles (NPs), because of their wide spectrum of activities and physical and chemi- cal properties, are nowadays extensively researched. However, careful studies on living organism should be performed, with strong attention to biocompatibility. Multiple cel- lular effects, displayed after AgNP treatments, show interesting potential of metal-based NPs, not only in bio-nanotechnology but also in molecular medicine and anticancer ther- apy. AgNPs are promising anticancer agents, influencing the cell cycle, inhibiting can- cer proliferation, and inducing oxidative stress and propagation of programmed cellular death (apoptosis). Additionally, they protect against bacterial, fungal, and viral infec- tions. During chemo- and radio-therapies, such antimicrobial protection will be desir- able because of the decreased immunological resistance of cancer patients. In conclusion, AgNPs often present in the human environment should be studied for novel findings and better characteristic. This article discusses advantages of AgNP’s “eco-friendly” pro- duction, followed by green synthesis, with particular consideration of antimicrobial and anticancer properties. Cellular processes, induced after AgNP treatments, are focused on antiproliferative, pro-oxidative, and pro-apoptotic activities of NPs. Keywords: