Soy allergy in patients with atopic dermatitis, sensitivity of ALEX2 Allergy Xplorer examination

Abstract

The aim of the current study was to evaluate the incidence of soy allergy in patients with atopic dermatitis (AD) and to evaluate the results of specific IgE against molecular components of soy. Altogether, 100 AD patients were examined. Soy allergy was confirmed in an open exposure test (history), and the presence of specific IgE against molecular components of soy (Gly m 4, Gly m 5, Gly m 6, Gly m 8) was evaluated using an ALEX2 Allergy Explorer test. The results for the measures of specific IgE against molecular components of soy (Gly m 4, Gly m 5, Gly m 6, Gly m 8) and clinical reactions in the open exposure test were then compared. Soy allergy was confirmed in 12% of patients. The sensitivity of specific IgE against Gly m 4 was 50.0% (21.1–78.9%). In another 29% of patients we recorded the positive results for specific IgE against Gly m 4 without any clinical reaction to soy. Compared to results from a previous study in 2013, there was an increase in the incidence of soy allergy in AD patients. An elimination diet and an exposure test are recommended to detect a reaction to soy. ALEX2 Allergy Xplorer test gives us a comprehensive picture of sensitization and the possibility of evaluation of cross-reacting allergens.