Synthesis and characterization of copper(II) complexes of adenine and aminoacids

Abstract

Complexes [Cu(CH3COO)(ade-H)(H2O)] H2O) (I), [Cu(CH3COO) (ade-H)(0-5ade) (0-5H2O)] 2H2O (la), [Cu(CH3COO)(ade-H)(ade)] 2H2O] (Ib), [Cu(ClCH2COO)(ade-H) (H2O)] H2O (II), [(Cu(CNCH2COO)(ade-H)(H2O)] H2O (III), where ade = adenine (C5H5N5), have been prepared. I, II and III on interaction with aminoacids such as glycine, alanine or glutamic acid give the complexes of the type [Cu(XCH2COO)(aa)(ade)(2H2O)], where X=H, Cl or CN and Haa = aminoacid, which arc characterized by elemental and thermal analyses, electronic, infrared and EPR spcctroscopic studies and variable temperature magnetic susceptibility measurements. Simple adeninato complexes are found to be dimeric, involving the bridging of the anionic adenine through the imidazole (N9) and the pyrimidine (N3) nitrogens and the acetato group through the carboxylate oxygens, while mixed adenine-aminoacidato complexes arc monomeric, involving the bonding of the N(7) of adenine, the oxygen of acetate and chclation of the aminoacid, in addition to the coordination of water molecules.