Ipratopium bromide in patients with nocturnal asthma

Abstract

Fourteen patients with nocturnal asthma were recruited to a two periodcrossover trial which compared a run-in period on nightly salbutamol (200 ug) with a period on nightly ipratropium bromide (160 ,ug) and a period on nightly salbutamol plus ipratropium at night. Morning dipping, as assessed by the fail in peak low overnight, was significantly reduced in the periods when ipratropium bromide was taken. Peak flow in the morning and also at night was improved when taking ipratropium bromide. Ipratropium bromide in adequate dosage appears to be effective in reducing morning dipping in asthma.