Au(I)-Catalyzed annulation of propargyl amine with Aldehydes: One-Pot cascade synthesis of 2,5-Dimethylpyrazines

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Abstract

3-Substituted 2,5-dimethylpyrazines were synthesized in high yields via a one-pot cascade annulation of easily available propargyl amine with aldehydes catalyzed by Au(PPh2Cy)Cl.

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Su, J., Liu, H., & Hua, R. (2015). Au(I)-Catalyzed annulation of propargyl amine with Aldehydes: One-Pot cascade synthesis of 2,5-Dimethylpyrazines. International Journal of Molecular Sciences, 16(2), 3599–3608. https://doi.org/10.3390/ijms16023599

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