Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells

Abstract

A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce 0.8 Gd 0.2 O 2−x) using a culture of mesenchymal stem cells. The absence of cyto-and genotoxicity over a wide range of concentrations (10 −5-10 −9 M) was demonstrated. At that, the highest concentration of Ce 0.8 Gd 0.2 O 2−x nanoparticles (10 −4 M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce 0.8 Gd 0.2 O 2−x nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.