Role of Urinary CTX I in Early Diagnosis of Osteoarthritis

Abstract

Introduction: The early diagnosis of osteoarthritis is required to do possible intervention in early stage of disease because it is one of the leading causes of disability in advance stage. For this reason various biomarker have been studied having merits and demerits of each. We chose urinary CTX-1 as biomarker to assess its role in osteoarthritis in knee joint. Methodology: the study included 100 patients of primary osteoarthritis of knee joint and 50 controls. They were subjected to WOMAC scoring and K-L grading and estimation of urinary CTX-I. Statistical analysis was done using SPSS software version 20.0. Results: Mean CTX-I levels of Control Group were 12.28±5.3ng/dl and in Case Group was 37.13±23.8 ng/dl and this difference was highly significant (p<0.001). Strong correlation was found between K-L grading and urinary CTX-I on Spearman's correlation coefficient. These associations were found to be highly significant (p<0.001). Receiver operator curve (ROC) analysis was done for prediction of cut-off values between Control group and Case group found >14.4ng/ml as cut-off point between Control group and Case group. Conclusion: Since CTX-I is biomarker of bone resorption and bone resorption is found more in case of progressive osteoarthritis of knee joint hence, we believe that CTX I levels can help in early identification of progressive OA cases.