Screening of glucose-6-phosphate dehydrogenase (G6PD) deficiency in two high endemic malaria populations, West Papua Province and North Moluccas

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a X-chromosomally transmitted disorder of the erythrocyte that affects 400 million people worldwide. In Indonesia, this affect become the burden in malaria treatment since primaquine, one of main therapy applied in Indonesia which causes a mild to severe acute haemolytic for G6PD deficiency persons. This study is on-going study to observe the prevalence of G6PD phenotypically and genetically.Aim of this study is to describe the prevalent of G6PD in two high endemic malaria deficiency area Papua and North Moluccas. Our total sampled was 179 residents consist of 82 samples from West Papua and 97 from North Mollucas. In the province we sampled from 3 separates districts. Analysis Screening of G6PD deficiency phenotypically was done using G6PD Care A Start G6PD rapid test using 3 µl venosus blood. The blood was dropped to the rapid diagnostic kit and read after 10 minutes but not more than 30 minutes. The purple color is interpreted as a normal but colorless is G6PD deficiency. Result show that phenotypically, 4.8 % of samples from West Papua are G6PD deficiency and 3% of North Moluccas samples are G6PD deficiency. Since the study area is malaria endemic area that becomes a warning to administered primaquine as a malaria theraphy to an individu with G6PD deficiency.