Induction of plasmid-carried qnrS1 in escherichia coli by naturally occurring quinolones and quorum-sensing signal molecules

Abstract

Naturally occurring quinolone and quinolone-like compounds, such as quinine, 2-hydroxyquinoline, 4-hydroxyquinoline, and 2-heptyl-3-hydroxy-4(1H)- quinolone, increased expression of qnrS1 in Escherichia coli 2.3-to 11.2-fold, similar to the synthetic quinolone ciprofloxacin. In contrast, chromosomal qnrVS1 of Vibrio splendidus was not induced by these compounds. Molecules associated with quorum sensing, such asN-3-hydroxybutyryl-homoserine lactone (HSL),N-hexanoyl-HSL, andN-3-(oxododecanoyl)-HSL, did not show an induction effect on either qnrS1 or qnrVS1 at the tested concentrations. Copyright © 2013, American Society for Microbiology. All Rights Reserved.