Synthesis of the novel 4,4′- and 6,6′- dihydroxamic-2,2′-bipyridines and improved routes to 4,4′- and 6,6′- substituted 2,2′-bipyridines and mono-N-oxide-2,2′-bipyridine

Abstract

The preparation of key precursors for many 2,2′-bipyridine derivatives such as 4,4′-dicarboxy-2,2′-bipyridine (I), 6,6′-dicarboxy-2,2′-bipyridine- acid (II), 4,4′-dinitro-2,2′-bipyridine-N,N-dioxide (III), 6,6′-dicarbothioamide-2,2′-bipyridine (IV) and mono-N-oxide-2,2′-bipyridine (VII) through more efficient methods is described. The syntheses of the novel ligands 4,4′-dihydroxamic-2,2′-bipyridine (V) and 6,6′-dihydroxamic-2,2′-bipyridine (VI) are also reported.