Preemptive Liver Transplantation from a Living Related Donor for Primary Hyperoxaluria Type I

Abstract

This case report demonstrates that preemptive liver transplantation from a living related donor for primary hy- peroxaluria type I can be accomplished without an im- mediate impairment in kidney function or the need for dialysis, despite the use of nephrotoxic tacrolimus-based immunosuppressive therapy. Even though there were oxa- late deposits in the patient’s kidneys before transplantation, eight months after transplantation her kidney function had not deteriorated further. Preemptive liver transplantation from a living related donor eliminates the long waiting time and thus the ongoing kidney damage associated with cadaveric donor transplantation and should therefore be considered for children with primary hyperoxaluria type I.