A concise synthesis of (±)-methoxyfumimycin ethyl ester

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Abstract

The protecting-group-free synthesis of (±)-methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase (PDF) inhibitor, is reported. The synthetic approach features a tandem Friedel-Crafts alkylation/lactonisation access as a key reaction to generate a, a-disubstituted amino acid unit. © 2014 Publishing Technology.

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Zhou, Z., Hu, Y., Wang, B., He, X., Ren, G., & Feng, L. (2014). A concise synthesis of (±)-methoxyfumimycin ethyl ester. Journal of Chemical Research, 38(6), 378–380. https://doi.org/10.3184/174751914X14011142030158

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