Dopamine agonists as genital endometriosis target therapy

Abstract

Objective: The present study was to find a pathogenic evidence for dopamine agonist application in patients with endometriosis associated pain syndrome. Patients and technique: The study involved 227 patients of reproductive age with histologically confirmed genital endometriosis (GE) of I–III degree according to ASRM classification. The control group included 12 women with no laparoscope detected gynecologic pathology. The levels of prolactin (PRL), peripheral blood (PB), and peritoneal fluid (PF) were evaluated by chemiluminescence immune assay. The pain syndrome was measured by McGill visual analogue scale. Statistica10 program (StatSoft, Inc., Tulsa, OK) was applied for obtained data processing. Results: A correlation was established between GE rate and levels of PRL and PB (Rs = 0.28, p