Development of Ketorolac Analysis in Water Samples using Micellar Electrokinetic Chromatography

Abstract

Quantitative determination of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) in water samples was reported using the micellar electrokinetic chromatography (MEKC) method. The on-line preconcentration technique at MEKC was then investigated to increase the detection sensitivity of ketorolac. A 6-fold increase in sensitivity factor was achieved using normal stacking mode (NSM)-MEKC. The average recovery of ketorolac in tap water samples was 102.16% (RSD = 0.06%). The current NSM-MEKC method is simple, has short analysis time, high accuracy, and uses fewer organic solvents (environmentally friendly).