Regulation of DC development and DC-mediated T-cell immunity via CISH

Abstract

Cytokine inducible SH2-containing protein (CISH) plays a crucial role in Type 1 dendritic cell (DC) development as wellas in the DC-mediated activation of cytotoxic T lymphocytes (CTLs). CISH expression at late DC developmental stagesshuts down the proliferation of DC progenitors by negatively regulating signal transducer and activator of transcription 5 (STAT5) and facilitates the differentiation of DCs into potent stimulators of CTLs. © 2013 Landes Bioscience.