Two rare meroterpenoidal rotamers from Ganoderma applanatum

Abstract

Applanatumols Z3 (1) and Z4 (2), two novel natural product hybrids consisting of a meroterpenoid and a glycerol and three known compounds (3-5) were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures were elucidated by means of spectroscopic methods, ECD and 13C NMR calculations. It is of particular interest that 1 and 2 are rare separable conformers. Racemic 1 and 2 were further separated by chiral HPLC to afford their respective enantiomers, whose biological activities were evaluated against JAK3 and DDR1 kinases.