Rhodium-catalyzed addition of organometallic reagents to carbon-hetero atom and electron deficient carbon-carbon double bonds

Abstract

Recent progress on the rhodium-catalyzed addition reactions of organometallic reagents to carbon-hetero atom and electron deficient carbon-carbon double bonds in such as aldehydes, ketones, imines, and α,β-unsaturated carbonyl compounds are described. The reactions are considered to involve the generation of the organorhodium intermediate by the transmetalation with the organometallic reagents, which actually adds to the substrates. A wide range of organometallic reagents such as tin, boron, silicon, lead, bismuth, titanium, and zirconium can be employed in these catalytic addition reactions. Highly enantioselective asymmetric additions have also been achieved using chiral ligands for rhodium complexes.