Nuclear RNA-protein interactions and messenger RNA processing

Abstract

Eucaryotic messenger RNA precursors are processed in nuclear ribonucleoprotein particles (hnRNP). Here recent work on the structure of hnRNP is reviewed, with emphasis on function. Detailed analysis of a specific case, the altered assembly of hnRNP in heat-shocked Drosophilia and mammalian cells, leads to a general hypothesis linking hnRNP structure and messenger RNA processing.