Development of Posttraumatic Hydrocephalus Requiring Ventriculoperitoneal Shunt After Decompressive Craniectomy for Traumatic Brain Injury: a Systematic Review and Meta-analysis of Retrospective Studies

Abstract

Background: Decompressive craniotomy (DC) is a known risk factor for the development of posttraumatic hydrocephalus (PTH) in the patients with traumatic brain injury (TBI). Herein, the present study reported the development of PTH requiring ventriculoperitoneal (VP) shunt after DC for TBI. Methods: Four databases (PubMed, Web of Science, Scopus, and Cochrane Library) were searched from 1983 to April 2018. The studies evaluating the prevalence of PTH requiring VP shunt after DC in the patients with TBIwere selected without language restriction. A random-effects meta-analysis using event rate (ER) and 95% confidence intervals(CIs), was runby RevMan5.3 software. Results: Out of 355 studies obtained from the databases, 25 studies were included and analyzed in the meta-analysis. The studies included 2402 patients undergoing DC for TBI, 354 of whohad PTH. The pooled ER of hydrocephalus in the patients undergoing DC for TBI was 17.7% [95%CI: 13.2 to 23.4%; P<0.001]. In addition, the pooled analysis showed that ER of hydrocephalus was 13% in adults [95%CI: 9 to 18.5%; P<0.001] and 37.6% in children [95%CI: 27.79 to 48.7%; P=0.029; I2=0%]. Conclusion: The present study demonstrated that DC after TBI was associated with the development of PTH, especially in children compared to adults.