Design, structure of amphiphilic peptide and its application from single molecule to nanoparticle

Abstract

Peptides have been widely studied for their good biocompatibility and diverse structural characteristics. Amphiphilic peptides, which have the special structure of hydrophilic one end and hydrophobic the other and self-assembly property, have a wide range of biological functions. Thus amphiphilic peptides become the focus of this paper. Based on the literature research and our previous study on self-designed amphiphilic peptides, this paper describes the design and structure of three kinds of amphiphilic peptides, and reviews their application in antibacterial, antitumor, tissue regeneration and drug carrier from single molecules to nanoparticles. The relationship between their structures, responsiveness, self-assembly and applications have been well represented. Amphiphilic peptides show significant advantages in smart materials that present a bright development prospect in biomedicine. This review will provide a theoretical basis for the design of functional peptides.