Abstract
Background: The mechanisms of placental growth factor (PlGF)-mediated blood vessel formation are incompletely understood. Results: Plasmin cleaves the heparin-binding domain of PlGF-2. Conclusion: Plasmin regulates PlGF-2/Neuropilin-1-mediated tissue vascularization and growth. Significance: Plasmin-mediated carboxyl-terminal processing of VEGF family members may be considered as a principal mechanism to regulate their biological activity. © 2013 by The American Society.
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CITATION STYLE
Hoffmann, D. C., Willenborg, S., Koch, M., Zwolanek, D., Müller, S., Becker, A. K. A., … Eming, S. A. (2013). Proteolytic processing regulates placental growth factor activities. Journal of Biological Chemistry, 288(25), 17976–17989. https://doi.org/10.1074/jbc.M113.451831
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