Batch and continuous flow preparation of hantzsch 1,4-dihydropyridines under microwave heating and simultaneous real- Time monitoring by raman spectroscopy. An exploratory study

Abstract

Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem's microwave- Assisted batch and continuous flow equipment. Real- Time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.