The relationship between the conformational degree of freedom of template-containing threads and slippage in the formation of [2]rotaxane building blocks

Abstract

A straightforward slippage strategy has been used for the synthesis of three [2]rotaxane building blocks that all contain an ammonium template for the dibenzo-24-crown-8 macrocycle and an N-hydroxysuccinimide end. The kinetic rate of the slipping-on process proved to be highly dependent on both the length and flexibility of the thread.