Magnetic resonance abnormalities and cardiovascular disease in older adults the cardiovascular health study

Abstract

Background and PurposeCerebral magnetic resonance imaging often detects abnormalities whose significance is unknown. The prevalence and correlates of findings such as ventricular enlargement, sulcal widening, and increased white matter signal intensity were examined in 303 men and women aged 65 to 95 years participating in a multicenter study of cardiovascular disease. MethodsCerebral magnetic resonance imaging was performed and interpreted according to a standard protocol, and findings were correlated with measures of cardiovascular disease and its risk factors. ResultsMeasures of cerebral atrophy increased with age and were greater in men than in women (each P