The correlation of matrix metalloproteinase-9 serum levels with clinicopathological factor in epithelial type ovarian cancer patients

Abstract

Objective: To determine correlation of serum matrix metalloprotein-9 level with peritoneal cancer index in epithelial type ovarian cancer patients. Methods: This study is a descriptive study with case series design on 26 subjects with epithelial type ovarian cancer at H. Adam Malik Hospital Medan in March to May 2018. Subjects were selected by consecutive sampling and blood samples was obtained from patients and serum MMP-9 levels was measured by ELISA. Data were analyzed using statistics Mann-Whitney test, t-test independent and Spearman correlation test. A p-value less than 0.05 is applied to each statistical test as significant. Results: From 26 patients. Most of the subject of study was above 50 years, have ≥ 1 children with a kind of histopathologic type adenocarcinoma serosum, stage III-IV and optimal cytoreduction. Histopathology type of 16 patients (61.5%) was serous adenocarcinoma, 5 patients (19.2%) were mucinous adenocarcinoma, and 5 patients (19.2%) were others. The median MMP-9 serum levels was highest with serous adenocarcinoma type (1002.6 ng/mL). Patients with CA-125> 500 U/mL, suboptimal cytoreduction, PCI score >10 had high MMP-9 serum levels with median 1530.2 ng/mL 2157.6 ng/mL and 1942.4 ng/mL respectively. Considerably higher than those with CA-125 ≤500 IU/mL optimal cytoreduction and PCI score ≤10. Menopausal status showed no significant difference with p-value 0.311. Conclusion: There is significant difference in serum MMP-9 level based on CA-125 level, cytoreduction and PCI. But serum MMP-9 level based on histopathology, menopausal state, and stage is not statistically different. PCI score is not statistically different in stage II and stage III-IV patients.