Rapid lipid enrichment in ω3 fatty acids: Liver data

Abstract

The bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion to normal subjects was recently reported to enrich within 60 min the phospholipid content of leucocytes and platelets in long-chain poly-unsaturated ω3 fatty acids. The present study, conducted in second generation ω3-depleted rats, aims at investigating whether such a procedure may also increase within 60 min the phospholipid content of ω3 fatty acids in cells located outwards of the bloodstream, in this case liver cells, and whether this coincides with correction of the perturbation in the liver triglyceride fatty acid content and profile otherwise prevailing in these rats. The results indicate that such is indeed the case and further suggest a cause-to-effect relationship between the two events.