Synthesis, spectral, DNA binding and cleavage properties of ruthenium(II) Schiff base complexes containing PPh3/AsPh3 as co-ligands

Abstract

Dihydroxybenzaldehyde-based Schiff base ligands (L1-L 3) and their ruthenium(II) complexes were synthesized and characterized by elemental analysis, 1H-, 13C- and 31P-NMR, UV-Vis, IR and mass spectroscopy. The DNA binding of the ruthenium(II) complexes was investigated by UV-Vis absorption spectroscopy. The experiments revealed that all the compounds could bind to DNA through electrostatic interactions and the intrinsic binding constants (Kb) were estimated under similar sets of experimental conditions. The absorption spectral study indicated that the ruthenium(II) complexes had intrinsic binding constants in the range of (1.6-8.6)×104 mol-1 dm3. The complex [Ru(CO)(PPh3)2(L3] bound more strongly than the other complexes. In addition, the DNA cleavage properties for all ruthenium(II) complexes were tested. © 2014 (CC) SCS.