Subtracted Adulthood Mass Index-a new index to predict NAFLD risk in non-obese individuals

Abstract

Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease. The aims of the current study are to deter-mine the relationship between NAFLD in non-obese individuals and weight gain during adulthood and develop a new index for the identification of NAFLD risk. Materials and Methods: For this cross-sectional study, 362 patients who underwent abdominal ultrasonography (USG) in our clinic were included. Seventy-eight individuals were obese (>30 kg/m2). A history of weight gain during adulthood and systemic metabolic diseases was collected at the time of the study. A new index termed “Subtracted Adulthood Mass Index” (SAMI) was created to estimate the risk of NAFLD development for non-obese people. SAMI is the ratio of the difference between the individual’s current weight and his/her weight at 20 years old to his/her height squared (kg/m2). Results: When the SAMI cut-off was set at 3 kg/m2, the sensitivity for pre-dicting NAFLD risk was 85.2%, the specificity was 66.9%, the PPV was 79.1%, and the NPV was 75.4%. Conclusion: In this innovational study, a new index named SAMI was de-veloped to identify non-obese people who are at risk of developing NA-FLD. The SAMI is easy to calculate and appropriate for clinical use.