A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Zhang Qingzhi; Kulczynska Agnieszka; David J. Webb; Ian L. Megson; Nigel P. Botting

Journal ArticleOPEN ACCESS

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Chemical Communications (2013) 49(14) 1389-1391

DOI: 10.1039/c2cc38382a

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Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF). © 2013 The Royal Society of Chemistry.

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Qingzhi, Z., Agnieszka, K., Webb, D. J., Megson, I. L., & Botting, N. P. (2013). A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation. Chemical Communications, 49(14), 1389–1391. https://doi.org/10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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