Abstract
Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.
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CITATION STYLE
Willey, J. S., Aunon-Chancellor, S., Miles, L. A., Moore, J. E., Mao, X. W., Wallace, R. W., & Foy, M. C. (2022). αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading. Npj Microgravity, 8(1). https://doi.org/10.1038/s41526-022-00203-w
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