090 HIGH RESOLUTION 3D CINE IMAGING: A NOVEL APPROACH FOR AUTOMATED RIGHT VENTRICULAR PHENOTYPING

  • Dawes T
  • de Marvao A
  • Keenan N
  • et al.
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Abstract

Background Despite technological advances in cardiac imaging, accurate phenotyping of the right ventricle (RV) remains challenging. Current cardiac magnetic resonance (CMR) methods have poor through-plane resolution limiting the accuracy of modelling the complex RV shape and dynamics. RV function and mass are increasingly recognised as pivotal in guiding treatment and establishing prognosis in cardiomyopathies and pulmonary hypertension. Here we acquire high resolution 3D cine imaging of the RV and exploit the advantages of this approach with automated segmentation. Methods We used a 1.5 T Philips Achieva system with a 32 element cardiac phased-array coil. 26 healthy volunteers from the GenScan (Genetic Studies of the Heart and Circulation) study were imaged. Short axis SSFP images were acquired: 2D: voxel size 2.0x2.2x8 mm, 12 sections, two sections per breath-hold, slice thickness 8 mm with 2 mm gap, 30 cardiac phases. 3D: single breath-hold 3D b-SSFP volumes: voxel size 2x2x4 mm (reconstructed to 2x2x2 mm), 48 sections, 20 cardiac phases, SENSE factor 4. Right ventricular 2D volumes were measured using CMRtools software. For the creation of the atlas each voxel in the 3D cine sequences obtained from five volunteers was manually labelled using ITKsnap software. Datasets from 21 other volunteers were non-rigidly registered to the 3D atlas. Images were segmented automatically using multi-atlas simultaneous segmentation and registration. (Figure presented) Results Presentation is confined to RV end-diastolic volumes (RVEDV) here. Data were log-transformed due to positive skewing (Normal plots, Shapiro-Wilk). 3D automated volumes were correlated with 2D manual volumes (rs=0.83, p

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APA

Dawes, T. J. W., de Marvao, A., Keenan, N. G., & O’Regan, D. P. (2013). 090 HIGH RESOLUTION 3D CINE IMAGING: A NOVEL APPROACH FOR AUTOMATED RIGHT VENTRICULAR PHENOTYPING. Heart, 99(suppl 2), A56.1-A56. https://doi.org/10.1136/heartjnl-2013-304019.90

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