Formulation And Evaluation Of Buccoadhesive Films of Lidocaine Hydrochloride

Abstract

The buccal region offers an attractive route of administration for systemic drug delivery. The aim of this study is to develop an innovative fast dissolving oral film (FDOF) of Famotidine. A buccal film for systemic administration of famotidine in the oral cavity has been developed using hydroxy propyl methyl cellulose -15cps (HPMC), carbopal(CP) and poly vinyl pyrrolidine (PVP) by solvent casting method. The physicochemical interactions between and polymers were investigated by Fourier transform infrared (FTIR)Spectroscopy. According to FTIR the drug did not show any evidence of an interaction with the polymers used and was present in an unchanged state. The films were evaluated for their physical characteristics like weight variation, thickness, drug content uniformity, surface pH, folding endurance, swelling percentage, percentage moisture absorption (PMA), percentage moisture loss (PML), water vapour transmission rate (WVT), mucoadhesion strength, Ex-vitro permeation studies. In vitro release studies were conducted for famotidine films in phosphate buffer (pH, 6.8) solution and the withdrawn solutions were thereafter analysed spectrophotometrically at 289 nm. A Total number of 8 formulations were prepared and In vitro drug release study of all the formulations showed that, from the formulation F8 the drug was released approximately upto 99.8% in 45 minutes. Hence formulation F8 was the best obtained formulation in the above study. Data of invitro release were fit into different equations and kinetic models to explain the release kinetics of Famotidine from the buccal films. The kinetic models used were a Zero-order equation, First order equation, Higuchi’s model and Peppa’s models. The correlation coefficient values (R2) indicate that the drug release was following zero order release kinetics. The mechanism of drug release was by peppas model indicates the super case II transport evidenced with diffusion exponent values (n) i.e > 0.89.