Palladium-Catalyzed C−H Iodination of N-(8-Quinolinyl)benzamide Derivatives Under Electrochemical and Non-Electrochemical Conditions

Abstract

Palladium-catalyzed ortho-selective C−H iodination of N-(8-quinolinyl)benzamides proceeded using I2 under both electrochemical and non-electrochemical conditions. The C−H iodination at 90 °C under base-free conditions provided high yields of the iodination products. The use of anodic oxidation increased the efficiency of the iodination at sterically-hindered positions.