Association of IL4, IL6, and IL10 polymorphisms with pulmonary tuberculosis in a Tibetan Chinese population

Abstract

Background: Pulmonary tuberculosis (PTB) is an infectious disease with a high incidence worldwide. Genes encoding cytokines IL4, IL6, and IL10 are highly polymorphic and can influence the susceptibility to PTB. Results: We found correlations between one SNP in IL6 (rs2069837 p = 6.63E-11), seven SNPs in IL10 (rs1554286 p = 6.87E-20, rs1518111 p = 6.11E-11, rs3021094 p = 6.75E-29, rs3790622 p = 2.40E-06, rs3024490 p = 6.73E-11, rs1800872 p = 6.18E-11, rs1800871 p = 6.73E-11) and incidences of PTB. The SNPs rs2069837, rs1554286, rs1518111, rs3024490, rs1800872, and rs1800871 increased PTB risk by 1.95-fold, 2.34-fold, 1.84-fold, 1.84-fold, 1.84-fold and 1.84-fold, respectively. The SNPs rs3021094 and rs3790622 decreased PTB risk by 0.33-fold and 0.38-fold, respectively. We also found two linkage disequilibrium blocks in the studied IL SNPs. The IL4 haplotype TCCCGGA (OR = 1.33, p = 0.014) increased PTB risk, the IL10 haplotypes ATGGATA (OR = 0.39, p = 4.84E-06) provided a protective effect and decreased PTB risk. Materials and Methods: For this study, we recruited 467 subjects with PTB and 503 healthy subjects from a Tibetan population living in Lhasa and nearby, China. Association analyses of sixteen single-nucleotide polymorphisms (SNPs) in IL4, IL6, and IL10 were performed. Conclusions: Our findings demonstrate an association between polymorphisms in IL6 and IL10 and risk of PTB.