Recent Advances in Image-Guided Tissue Sampling

Abstract

Recent advances in image-guided tissue sampling have enhanced diagnostic medicine, particularly in oncology. Traditional techniques, such as computed tomography (CT)-, ultrasound (US)-, and magnetic resonance imaging (MRI)-guided biopsies, remain the cornerstone of diagnostic interventions, each offering unique advantages based on tissue characteristics. CT-guided biopsies excel in deeper complex lesions, while US-guided biopsies provide real-time imaging ideal for superficial tissues. MRI-guided biopsies are invaluable for soft tissue evaluations. The emergence of fusion imaging, which combines modalities such as positron emission tomography (PET)/CT or MRI/US, has demonstrated enhanced diagnostic accuracy. Despite these advantages, image co-registration and cost are the main drawbacks. Emerging techniques such as molecular breast imaging (MBI) and shear wave elastography (SWE) have been evaluated, particularly for breast cancer; however, research suggests that US is likely to remain the most effective modality due to both its cost and ease of use. Innovations in biopsy navigation, including augmented reality, “hot needles,” and robotic assistance, demonstrate promise in closing the gap between operator dependency and procedural consistency; however, further research is required. While liquid biopsies show promise in non-invasive early cancer detection, they are not yet ready to replace tissue biopsies. Collectively, these advancements indicate a future where image-guided tissue sampling is more targeted, less invasive, and diagnostically accurate, although cost and technology access remain challenges.