Abdominal Aortic Aneurysm Repair Using the Multilayer Flow Modulator in Porcine Animal Models

Abstract

This study tested the hypothesis that the Multilayer Flow Modulator (Cardiatis, Isnes, Brussels) can treat aortic aneurysms through intra-arterial hemodynamic modulation, without substantial parent or small branch artery compromise, using 8 porcine models. The animals were euthanized and devices explanted upon completion of the study for examination. Results of the delivery system evaluation showed that there were no difficulties during navigation of the device through the arteries. An overall trend of reduction in aneurysm size was recorded. The opening of the aneurysm was nearly occluded with thrombus in 2 of the explants. The visceral arteries covered by the device remained patent, and it adhered to the arterial wall with endothelialization clearly visible. The MFM was therefore placed without intra-arterial compromise, and the aneurysms were stabilized while adequate blood flow to the collateral arteries was preserved.