Association of CAPN10 SNP-19 (rs3842570) polymorphism on fasting plasma glucose, blood pressure and body mass index of Javanese type-2 diabetes patients

Abstract

Polymorphism of CAPN10 has been reported to be responsible for risk of Type 2 Diabetes Mellitus (T2DM), and CAPN 10 SNP-19 (rs3842570) is associated with elevation of blood glucose, obesity, and metabolic syndrome. Aims of this study are to analyze the association between polymorphism CAPN10 SNP-19 (rs3842570) on fasting plasma glucose (FPG), blood pressure (BP) and body mass index (BMI) of Javanese T2DM patients. The study sample comprised 107 T2DM subjects as well as 107 healthy subjects of Javanese origin. T2DM subjects were obtained from several Primary Public Health Centers in Semarang. The polymorphism of CAPN10 SNP19 was examined using PCR. FPG, BP, and BMI also were examined. The association between FPG, BP, and BMI in each genotype class was analyzed using Kruskal Wallis test. In the T2DM group, the 2R/3R genotype had the highest mean of FPG (138,42±6,77mg/dl), BMI (26,49±0,41). However, the highest mean of blood pressure was 2R/2R genotype with systolic 142,00±7,27mmHg and diastolic 83,11± 3, 17mmHg.There was no significant association between polymorphism in T2DM group with FPG, systolic BP, diastolic BP and BMI with p-value 0,563; 0,734; 0,939; 0,087, respectively. In conclusion, CAPN10 SNP-19 (rs3842570) polymorphism does not contribute to elevating FPG, BP, and BMI of Javanese T2DM patients.