Effects of d-allose in combination with docetaxel in human head and neck cancer cells

Abstract

In this study we investigated the combined effects of docetaxel and d-allose in HSC3 human oral carcinoma cells. The dose enhancement ratios at the 25% survival level were 1.3 and 1.71 for combined treatment with 10 or 25 mM d-allose, respectively. Apoptosis was significantly increased by addition of d-allose. Additionally, a synchronous increase in the G2/M-phase population was observed after docetaxel plus d-allose treatment. In vivo experiments revealed that docetaxel plus d-allose was more effective than either agent alone. Thus, d-allose enhanced the anticancer effects of docetaxel, and combined treatment may be useful to achieve clinical efficacy with reduced toxicity.